BDBM621967 (S)-N-((R or S)-(8,8-difluorobicyclo[4.2.0]octa-1::US11802122, Example 89::US20230312528, Example 89

SMILES FC(F)(F)Oc1ccc(cc1)C(NC(=O)[C@@H]1CNC(=O)N1)c1ccc2CC(F)(F)c2c1

InChI Key InChIKey=IFYLHXKCTRQABW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 621967   

TargetSodium channel protein type 8 subunit alpha(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM621967(US20230312528, Example 89 | US11802122, Example 89...)
Affinity DataIC50: 4.90nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
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TargetSodium channel protein type 8 subunit alpha(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM621967(US20230312528, Example 89 | US11802122, Example 89...)
Affinity DataIC50: 4.90nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
Go to US Patent