BDBM621965 (S)-N-((R or S)- benzo[d]thiazol-2- yl(3-chloro-4- fluoro- phenyl)methyl)-2- oxoimidazolidine-4- carboxamide::US11802122, Example 87::US20230312528, Example 87

SMILES Fc1ccc(cc1Cl)C(NC(=O)[C@@H]1CNC(=O)N1)c1nc2ccccc2s1

InChI Key InChIKey=GYHUDROTRROGQH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 621965   

TargetSodium channel protein type 8 subunit alpha(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM621965(US20230312528, Example 87 | US11802122, Example 87...)
Affinity DataIC50: 2.90nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
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TargetSodium channel protein type 8 subunit alpha(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM621965(US20230312528, Example 87 | US11802122, Example 87...)
Affinity DataIC50: 2.90nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
Go to US Patent