BDBM621856 (S)-N-((R or S)-(3- chloro-4- fluorophenyl)(1- methyl-3-(tri- fluoromethyl)-1H- pyrazol-5-yl)methyl)- 2-oxoimidazolidine-4- carboxamide::US11802122, Example 31B::US20230312528, Example 31B

SMILES Cn1nc(cc1C(NC(=O)[C@@H]1CNC(=O)N1)c1ccc(F)c(Cl)c1)C(F)(F)F

InChI Key InChIKey=QTYZDTWKFLHENC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 621856   

TargetSodium channel protein type 8 subunit alpha(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM621856(US20230312528, Example 31B | US11802122, Example 3...)
Affinity DataIC50: 5.20nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
Go to US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM621856(US20230312528, Example 31B | US11802122, Example 3...)
Affinity DataIC50: 268nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
Go to US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM621856(US20230312528, Example 31B | US11802122, Example 3...)
Affinity DataIC50: 268nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
Go to US Patent