BDBM617836 6-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-N-((1-(2,3-dimethyl-4-((1R,5S)-2-oxo-3-azabicyclo[3.1.0]hexan-3-yl)benzyl)-1H-pyrazol-::US20230286958, Example 48

SMILES Cc1c(Cn2cc(NC(=O)c3cncc(n3)-c3c(F)c(Cl)ccc3C(F)F)cn2)ccc(N2C[C@H]3C[C@H]3C2=O)c1C

InChI Key InChIKey=CIEATFLQWXVGIZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 617836   

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM617836(6-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-N-(...)
Affinity DataIC50: 0.600nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
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Date in BDB:
10/23/2023
Entry Details
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TargetCoagulation factor XI(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM617836(6-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-N-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:Assays were conducted at room temperature or at 37° C. Hydrolysis of the substrate resulted in release of amino trifluoromethylcoumarin (AFC), which ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
Go to US Patent