BDBM6154 1,6-naphthyridine 23::3-tert-butyl-1-(7-{[4-(diethylamino)butyl]amino}-3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-2-yl)urea::N-(tert-Butyl)-N -[7-[[4-(diethylamino)butyl]amino]-3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-2-yl]urea

SMILES CCN(CC)CCCCNc1cc2nc(NC(=O)NC(C)(C)C)c(cc2cn1)-c1cc(OC)cc(OC)c1

InChI Key InChIKey=YMKCMNJQFGEWCA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 6154   

TargetPlatelet-derived growth factor receptor beta(Mouse)
University of Auckland

LigandPNGBDBM6154(N-(tert-Butyl)-N -[7-[[4-(diethylamino)butyl]amino...)
Affinity DataIC50: 2.60E+3nMAssay Description:Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
University of Auckland

LigandPNGBDBM6154(N-(tert-Butyl)-N -[7-[[4-(diethylamino)butyl]amino...)
Affinity DataIC50: 25nMAssay Description:Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2005
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Auckland

LigandPNGBDBM6154(N-(tert-Butyl)-N -[7-[[4-(diethylamino)butyl]amino...)
Affinity DataIC50: 4.60E+3nMAssay Description:Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2005
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Auckland

LigandPNGBDBM6154(N-(tert-Butyl)-N -[7-[[4-(diethylamino)butyl]amino...)
Affinity DataIC50: 6nMAssay Description:Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2005
Entry Details Article
PubMed