BDBM614963 US20230271939, Compound Example 1::US20230271939, Example 1

SMILES COc1ncc(Cl)cc1S(=O)(=O)Nc1nccc(C#Cc2cnc(N)nc2)c1F

InChI Key InChIKey=ZHEOLZYPHNHWHG-UHFFFAOYSA-N

Data  4 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 614963   

TargeteIF-2-alpha kinase GCN2(Human)
Ip2Ipo Innovations

US Patent
LigandPNGBDBM614963(US20230271939, Example 1 | US20230271939, Compound...)
Affinity DataIC50: 7.20nMAssay Description:The inhibitory activity of the Example compounds towards GCN2 enzyme was measured according to the description below, using a LanthaScreen TR-FRET (T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2023
Entry Details
Go to US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Ip2Ipo Innovations

US Patent
LigandPNGBDBM614963(US20230271939, Example 1 | US20230271939, Compound...)
Affinity DataIC50: 103nMAssay Description:The inhibitory activity of the Example compounds towards GCN2 enzyme was measured according to the description below, using a LanthaScreen TR-FRET (T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2023
Entry Details
Go to US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Ip2Ipo Innovations

US Patent
LigandPNGBDBM614963(US20230271939, Example 1 | US20230271939, Compound...)
Affinity DataIC50: 7.20nMAssay Description:The inhibitory activity of the Example compounds towards GCN2 enzyme was measured according to the description below, using a LanthaScreen TR-FRET (T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2023
Entry Details
Go to US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Ip2Ipo Innovations

US Patent
LigandPNGBDBM614963(US20230271939, Example 1 | US20230271939, Compound...)
Affinity DataIC50: 103nMAssay Description:The inhibitory activity of the Example compounds towards GCN2 enzyme was measured according to the description below, using a LanthaScreen TR-FRET (T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2023
Entry Details
Go to US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Ip2Ipo Innovations

US Patent
LigandPNGBDBM614963(US20230271939, Example 1 | US20230271939, Compound...)
Affinity DataKi:  1.60nMAssay Description:The inhibitory activity of the Example compounds towards GCN2 enzyme was measured according to the description below, using a LanthaScreen TR-FRET (T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2023
Entry Details
Go to US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Ip2Ipo Innovations

US Patent
LigandPNGBDBM614963(US20230271939, Example 1 | US20230271939, Compound...)
Affinity DataKi:  1.60nMAssay Description:The inhibitory activity of the Example compounds towards GCN2 enzyme was measured according to the description below, using a LanthaScreen TR-FRET (T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2023
Entry Details
Go to US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Ip2Ipo Innovations

US Patent
LigandPNGBDBM614963(US20230271939, Example 1 | US20230271939, Compound...)
Affinity DataKi:  2.30nMAssay Description:The inhibitory activity of the Example compounds towards GCN2 enzyme was measured according to the description below, using a LanthaScreen TR-FRET (T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2023
Entry Details
Go to US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Ip2Ipo Innovations

US Patent
LigandPNGBDBM614963(US20230271939, Example 1 | US20230271939, Compound...)
Affinity DataKi:  2.30nMAssay Description:The inhibitory activity of the Example compounds towards GCN2 enzyme was measured according to the description below, using a LanthaScreen TR-FRET (T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2023
Entry Details
Go to US Patent