BDBM6147 1,6-naphthyridine 16::1-[3-(3,5-dimethoxyphenyl)-7-{[3-(4-methylpiperazin-1-yl)propyl]amino}-1,6-naphthyridin-2-yl]-3-ethylurea::N-[3-(3,5-Dimethoxyphenyl)-7-[[3-(4-methyl-1-piperazinyl)propyl]amino]-1,6-naphthyridin-2-yl]-N -ethylurea

SMILES CCNC(=O)Nc1nc2cc(NCCCN3CCN(C)CC3)ncc2cc1-c1cc(OC)cc(OC)c1

InChI Key InChIKey=KZMWAICISUWYLE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 6147   

TargetPlatelet-derived growth factor receptor beta(Mouse)
University of Auckland

LigandPNGBDBM6147(1-[3-(3,5-dimethoxyphenyl)-7-{[3-(4-methylpiperazi...)
Affinity DataIC50: 3.00E+4nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
University of Auckland

LigandPNGBDBM6147(1-[3-(3,5-dimethoxyphenyl)-7-{[3-(4-methylpiperazi...)
Affinity DataIC50: 21nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2005
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Auckland

LigandPNGBDBM6147(1-[3-(3,5-dimethoxyphenyl)-7-{[3-(4-methylpiperazi...)
Affinity DataIC50: 1.40E+4nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2005
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Auckland

LigandPNGBDBM6147(1-[3-(3,5-dimethoxyphenyl)-7-{[3-(4-methylpiperazi...)
Affinity DataIC50: 51nMpH: 7.8 T: 2°CAssay Description:Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2005
Entry Details Article
PubMed