BDBM6146 1,6-naphthyridine 15::3-(3,5-Dimethoxyphenyl)-N7-[3-(4-methyl-1-piperazinyl)-propyl]-1,6-naphthyridine-2,7-diamine::3-(3,5-dimethoxyphenyl)-7-N-[3-(4-methylpiperazin-1-yl)propyl]-1,6-naphthyridine-2,7-diamine

SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCN3CCN(C)CC3)cc2nc1N

InChI Key InChIKey=NLUPPEQIXOCYEE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 6146   

TargetPlatelet-derived growth factor receptor beta(Mouse)
University of Auckland

LigandPNGBDBM6146(3-(3,5-dimethoxyphenyl)-7-N-[3-(4-methylpiperazin-...)
Affinity DataIC50: 5.00E+4nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
University of Auckland

LigandPNGBDBM6146(3-(3,5-dimethoxyphenyl)-7-N-[3-(4-methylpiperazin-...)
Affinity DataIC50: 44nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2005
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Auckland

LigandPNGBDBM6146(3-(3,5-dimethoxyphenyl)-7-N-[3-(4-methylpiperazin-...)
Affinity DataIC50: 5.00E+4nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2005
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Auckland

LigandPNGBDBM6146(3-(3,5-dimethoxyphenyl)-7-N-[3-(4-methylpiperazin-...)
Affinity DataIC50: 180nMpH: 7.8 T: 2°CAssay Description:Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2005
Entry Details Article
PubMed