BDBM613784 (R)-(3-(3-ethyl-1,2,4- oxadiazol-5-yl)-8-methyl- 5,6-dihydro- [1,2,4]triazolo[4,3- a]pyrazin-7(8H)-yl)(4- (thiophen-2- yl)phenyl)methanone::US11731974, Compound 30

SMILES CCc1noc(n1)-c1nnc2CN(CCn12)C(=O)c1ccc(cc1)-c1cccs1

InChI Key InChIKey=HDLIEEINOUPIGR-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 613784   

TargetNeuromedin-K receptor(Human)
Ogeda

US Patent
LigandPNGBDBM613784(US11731974, Compound 30 | (R)-(3-(3-ethyl-1,2,4- o...)
Affinity DataKi:  7nMAssay Description:The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist3 H-SB222200 was assessed by an in vitro ra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2023
Entry Details
Go to US Patent

TargetNeuromedin-K receptor(Human)
Ogeda

US Patent
LigandPNGBDBM613784(US11731974, Compound 30 | (R)-(3-(3-ethyl-1,2,4- o...)
Affinity DataKi:  7nMAssay Description:The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist3 H-SB222200 was assessed by an in vitro ra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2023
Entry Details
Go to US Patent

TargetSubstance-K receptor(Human)
Ogeda

US Patent
LigandPNGBDBM613784(US11731974, Compound 30 | (R)-(3-(3-ethyl-1,2,4- o...)
Affinity DataKi:  3.20E+4nMAssay Description:The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2023
Entry Details
Go to US Patent

TargetSubstance-P receptor(Human)
Ogeda

US Patent
LigandPNGBDBM613784(US11731974, Compound 30 | (R)-(3-(3-ethyl-1,2,4- o...)
Affinity DataKi:  4.00E+4nMAssay Description:The affinity of compounds of the invention for the NK-1 receptor was evaluated in CHO recombinant cells which express the human NK-1 receptor. Membra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2023
Entry Details
Go to US Patent