BDBM612772 US11725005, Compound 113

SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cncc(c3)-c3cc(C)n[nH]3)c2)CC1

InChI Key InChIKey=YMHOIAKNPORUIV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 612772   

TargetTyrosine-protein kinase ABL1(Human)
Inhibikase Therapeutics

US Patent
LigandPNGBDBM612772(US11725005, Compound 113)
Affinity DataIC50: 35nMAssay Description:Kinase base buffer (50 mM HEPES, pH 7.5 0.0015% Brij-35; 10 mM MgCl22 mM DTT) and Stop buffer (100 mM HEPES, pH 7.5 0.015% Brij-35; 0.2% Coating Reag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2023
Entry Details
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TargetTyrosine-protein kinase ABL2(Human)
Inhibikase Therapeutics

US Patent
LigandPNGBDBM612772(US11725005, Compound 113)
Affinity DataIC50: 50.1nMAssay Description:Kinase base buffer (50 mM HEPES, pH 7.5 0.0015% Brij-35; 10 mM MgCl22 mM DTT) and Stop buffer (100 mM HEPES, pH 7.5 0.015% Brij-35; 0.2% Coating Reag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2023
Entry Details
Go to US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
Inhibikase Therapeutics

US Patent
LigandPNGBDBM612772(US11725005, Compound 113)
Affinity DataIC50: 7.5nMAssay Description:Kinase base buffer (50 mM HEPES, pH 7.5 0.0015% Brij-35; 10 mM MgCl22 mM DTT) and Stop buffer (100 mM HEPES, pH 7.5 0.015% Brij-35; 0.2% Coating Reag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase ABL1(Human)
Inhibikase Therapeutics

US Patent
LigandPNGBDBM612772(US11725005, Compound 113)
Affinity DataIC50: 108nMAssay Description:Kinase base buffer (50 mM HEPES, pH 7.5 0.0015% Brij-35; 10 mM MgCl22 mM DTT) and Stop buffer (100 mM HEPES, pH 7.5 0.015% Brij-35; 0.2% Coating Reag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase ABL2(Human)
Inhibikase Therapeutics

US Patent
LigandPNGBDBM612772(US11725005, Compound 113)
Affinity DataIC50: 203nMAssay Description:Kinase base buffer (50 mM HEPES, pH 7.5 0.0015% Brij-35; 10 mM MgCl22 mM DTT) and Stop buffer (100 mM HEPES, pH 7.5 0.015% Brij-35; 0.2% Coating Reag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2023
Entry Details
Go to US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
Inhibikase Therapeutics

US Patent
LigandPNGBDBM612772(US11725005, Compound 113)
Affinity DataIC50: 8.90nMAssay Description:Kinase base buffer (50 mM HEPES, pH 7.5 0.0015% Brij-35; 10 mM MgCl22 mM DTT) and Stop buffer (100 mM HEPES, pH 7.5 0.015% Brij-35; 0.2% Coating Reag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2023
Entry Details
Go to US Patent