BDBM610672 5-[(2S,6R)-2-[[4-(4-hydroxy-1,2,3,4-tetrahydroisoquinolin-6-yl)piperazin-1-yl]methyl]-6-methyl-morpholin-4-yl]quinoline-8-carbonitrile::US11713327, Example 22

SMILES C[C@@H]1CN(C[C@H](CN2CCN(CC2)c2ccc3CNCC(O)c3c2)O1)c1ccc(C#N)c2ncccc12

InChI Key InChIKey=JBZYFDJCNMVKCQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 610672   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM610672(US11713327, Example 22 | 5-[(2S,6R)-2-[[4-(4-hydro...)
Affinity DataIC50: 2.00E+4nMAssay Description:The hERG channel inhibition assay is a highly sensitive measurement that identifies compounds exhibiting hERG inhibition related to cardiotoxicity in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2023
Entry Details
Go to US Patent