BDBM610462 N-(4-Morpholinopyridin-3-yl)-2-phenylimidazo[1,2-b]pyridazine-8-carboxamide::US10774086, Example 13

SMILES O=C(Nc1cnccc1N1CCOCC1)c1ccnn2cc(nc12)-c1ccccc1

InChI Key InChIKey=KZAWBYUYDLDFQY-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 610462   

TargetGlycogen synthase kinase-3 beta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610462(US10774086, Example 13 | N-(4-Morpholinopyridin-3-...)
Affinity DataIC50: 0.400nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2023
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610462(US10774086, Example 13 | N-(4-Morpholinopyridin-3-...)
Affinity DataIC50: 0.200nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2023
Entry Details
Go to US Patent

TargetMicrotubule-associated protein tau(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610462(US10774086, Example 13 | N-(4-Morpholinopyridin-3-...)
Affinity DataIC50: 36nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2023
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610462(US10774086, Example 13 | N-(4-Morpholinopyridin-3-...)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMicrotubule-associated protein tau(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610462(US10774086, Example 13 | N-(4-Morpholinopyridin-3-...)
Affinity DataIC50: 36nMAssay Description:Inhibition of tau 4R1N phosphorylation (unknown origin) at S396 residue transfected in human U2OS cells coexpressing GFP-tagged beta catenin incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed