BDBM610457 N-(4-(4-Cyanophenyl)pyridin-3-yl)-2-phenylimidazo[1,2-b]pyridazine-8-carboxamide::US10774086, Example 8

SMILES O=C(Nc1cnccc1-c1ccc(cc1)C#N)c1ccnn2cc(nc12)-c1ccccc1

InChI Key InChIKey=NDAFUJBJGDJBNC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 610457   

TargetGlycogen synthase kinase-3 beta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610457(US10774086, Example 8 | N-(4-(4-Cyanophenyl)pyridi...)
Affinity DataIC50: 1.10nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2023
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610457(US10774086, Example 8 | N-(4-(4-Cyanophenyl)pyridi...)
Affinity DataIC50: 0.300nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2023
Entry Details
Go to US Patent

TargetMicrotubule-associated protein tau(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610457(US10774086, Example 8 | N-(4-(4-Cyanophenyl)pyridi...)
Affinity DataIC50: 160nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2023
Entry Details
Go to US Patent