BDBM610454 N-(4-(Methylsulfonyl)pyridin-3-yl)-2-phenylimidazo[1,2-b]pyridazine-8-carboxamide::US10774086, Example 5

SMILES CS(=O)(=O)c1ccncc1NC(=O)c1ccnn2cc(nc12)-c1ccccc1

InChI Key InChIKey=DHZZLYIYWJJLRB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 610454   

TargetGlycogen synthase kinase-3 beta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610454(US10774086, Example 5 | N-(4-(Methylsulfonyl)pyrid...)
Affinity DataIC50: 1.5nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610454(US10774086, Example 5 | N-(4-(Methylsulfonyl)pyrid...)
Affinity DataIC50: 0.400nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMicrotubule-associated protein tau(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610454(US10774086, Example 5 | N-(4-(Methylsulfonyl)pyrid...)
Affinity DataIC50: 120nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610454(US10774086, Example 5 | N-(4-(Methylsulfonyl)pyrid...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
In DepthDetails
PubMed