BDBM609871 (rac)-(2s,4s)-2-(6-(4-(tert-Butyl)phenyl)-3-azabicyclo[4.1.0]heptane-3- carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one::US11708359, Example 62::US11974987, Example 62

SMILES CC(C)(C)c1ccc(cc1)C12CC1CN(CC2)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2

InChI Key InChIKey=NNHYRRANFLKUBY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 609871   

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM609871(US11708359, Example 62 | (rac)-(2s,4s)-2-(6-(4-(te...)
Affinity DataIC50: 0.0190nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/4/2024
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM609871(US11708359, Example 62 | (rac)-(2s,4s)-2-(6-(4-(te...)
Affinity DataIC50: 0.0190nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM609871(US11708359, Example 62 | (rac)-(2s,4s)-2-(6-(4-(te...)
Affinity DataIC50: 0.0190nMAssay Description:Inhibition of MGL activity in human HeLa cells assessed as reduction in cleaved [1,3-3H glycerol] level using [glycerol-1,3-3H]-oleoyl glycerol as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed