BDBM60890 BDBM50392251::US9200020, Table 3 compound 5B

SMILES OP(O)(=O)CCN(CCC#N)CCn1cnc2c1nc[nH]c2=O

InChI Key

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 60890   

TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
The University of Queensland

US Patent
LigandPNGBDBM60890(BDBM50392251 | US9200020, Table 3 compound 5B)
Affinity DataKi:  200nM ΔG°:  -9.50kcal/moleT: 2°CAssay Description:The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitro ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHypoxanthine phosphoribosyltransferase(Plasmodium vivax)
The University of Queensland

US Patent
LigandPNGBDBM60890(BDBM50392251 | US9200020, Table 3 compound 5B)
Affinity DataKi:  700nM ΔG°:  -8.73kcal/moleT: 2°CAssay Description:The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitro ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHypoxanthine-guanine phosphoribosyltransferase(Human)
The University of Queensland

US Patent
LigandPNGBDBM60890(BDBM50392251 | US9200020, Table 3 compound 5B)
Affinity DataKi:  2.40E+3nM ΔG°:  -7.97kcal/moleT: 2°CAssay Description:The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitro ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHypoxanthine-guanine phosphoribosyltransferase(Human)
The University of Queensland

US Patent
LigandPNGBDBM60890(BDBM50392251 | US9200020, Table 3 compound 5B)
Affinity DataKi:  2.40E+3nMAssay Description:Inhibition of human HGPRTMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHypoxanthine-guanine phosphoribosyltransferase(Human)
The University of Queensland

US Patent
LigandPNGBDBM60890(BDBM50392251 | US9200020, Table 3 compound 5B)
Affinity DataKi:  2.40E+3nMAssay Description:Inhibition of human HGPRT using Prib-PP as substrate by spectrophotometric assay in presence of guanineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed