BDBM60880 US9200020, Table 1, Compound 1B

SMILES OP(O)(=O)CCOCCn1cnc2c1nc[nH]c2=O

InChI Key

Data  2 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 60880   

TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
The University of Queensland

US Patent
LigandPNGBDBM60880(US9200020, Table 1, Compound 1B)
Affinity DataKi:  300nM ΔG°:  -9.25kcal/moleT: 2°CAssay Description:The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitro ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHypoxanthine-guanine phosphoribosyltransferase(Human)
The University of Queensland

US Patent
LigandPNGBDBM60880(US9200020, Table 1, Compound 1B)
Affinity DataKi:  3.60E+3nM ΔG°:  -7.72kcal/moleT: 2°CAssay Description:The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitro ...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)