BDBM608389 (Z)-15-chloro-25-(difluoromethyl)-96-fluoro- 13,21,61-trimethyl-4-(methylsulfonyl)- 11H,21H,61H-10-oxa-8-thia-4-aza-1(4,1)- indola-2(4,3),6(3,5)-dipyrazola-9(3,1)- naphthalenacyclotridecaphane-12-carboxylic acid::US11691989, Compound 45

SMILES Cc1c(C(O)=O)n2CCCOc3cc(SCc4cc(CN(Cc5nn(C)c(C(F)F)c5-c5c(Cl)ccc2c15)S(C)(=O)=O)nn4C)cc1cc(F)ccc31

InChI Key InChIKey=NSMBFUKUGFDRSR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 608389   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-323](Human)
Ascentage Pharma (Suzhou)

US Patent
LigandPNGBDBM608389(US11691989, Compound 45 | (Z)-15-chloro-25-(difluo...)
Affinity DataIC50: 16nMAssay Description:The relative binding potency of representative Compounds of the Disclosure was determined by a fluorescence polarization (FP) assay. The method used ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent