BDBM60631 BDBM50447096::US9133168, 19b

SMILES C[C@H]1Cc2ccccc2N1C(=O)Cc1nc(cc(=O)[nH]1)N1CCOCC1

InChI Key InChIKey=UAXHPOBBKRWJGA-UHFFFAOYSA-N

Data  16 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 60631   

TargetRAC-alpha serine/threonine-protein kinase(Human)
Sanofi

US Patent
LigandPNGBDBM60631(BDBM50447096 | US9133168, 19b)
Affinity DataIC50: 16nMAssay Description:This test is based on measurement of the expression of AKT protein phosphorylated on serine 473 (P-AKT-S473) in the PC3 human prostate carcinoma line...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2016
Entry Details
Go to US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Sanofi

US Patent
LigandPNGBDBM60631(BDBM50447096 | US9133168, 19b)
Affinity DataIC50: 27nMAssay Description:This test is based on measurement of the expression of AKT protein phosphorylated on serine 473 (P-AKT-S473) in the PC3 human prostate carcinoma line...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2016
Entry Details
Go to US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Sanofi

US Patent
LigandPNGBDBM60631(BDBM50447096 | US9133168, 19b)
Affinity DataIC50: 19nMAssay Description:This test is based on measuring the expression of the AKT protein phosphorylated on serine 473 (P-AKT-S473), in the PC3 human prostate carcinoma line...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Sanofi

Curated by ChEMBL
LigandPNGBDBM60631(BDBM50447096 | US9133168, 19b)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of recombinant human CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
LigandPNGBDBM60631(BDBM50447096 | US9133168, 19b)
Affinity DataIC50: 60nMAssay Description:Inhibition of PI3Kbeta-mediated Akt phosphorylation at S473 in BRAF-V600E/PTEN-deficient human UACC62 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM60631(BDBM50447096 | US9133168, 19b)
Affinity DataIC50: 23nMAssay Description:Inhibition of N-terminal ploy-His-tagged human PI3Kbeta expressed in baculovirus-infected sf21 cells using PI(4,5)P2 as substrate after 15 mins by HT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM60631(BDBM50447096 | US9133168, 19b)
Affinity DataIC50: 468nMAssay Description:Inhibition of N-terminal ploy-His-tagged human PI3Kdelta expressed in baculovirus-infected sf9 cells using PI(4,5)P2 as substrate after 15 mins by HT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM60631(BDBM50447096 | US9133168, 19b)
Affinity DataIC50: 1.54E+3nMAssay Description:Inhibition of N-terminal ploy-His-tagged human PI3Kalpha expressed in baculovirus-infected sf9 cells using PI(4,5)P2 as substrate after 15 mins by HT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
LigandPNGBDBM60631(BDBM50447096 | US9133168, 19b)
Affinity DataIC50: 183nMAssay Description:Inhibition of VPS34 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
LigandPNGBDBM60631(BDBM50447096 | US9133168, 19b)
Affinity DataIC50: 3.81E+3nMAssay Description:Inhibition of PI3KC2gamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
LigandPNGBDBM60631(BDBM50447096 | US9133168, 19b)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PI3KC2beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
LigandPNGBDBM60631(BDBM50447096 | US9133168, 19b)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3KC2alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
LigandPNGBDBM60631(BDBM50447096 | US9133168, 19b)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of DNA-PK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Sanofi

Curated by ChEMBL
LigandPNGBDBM60631(BDBM50447096 | US9133168, 19b)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
LigandPNGBDBM60631(BDBM50447096 | US9133168, 19b)
Affinity DataIC50: 49nMAssay Description:Inhibition of N-terminal ploy-His-tagged human PI3Kbeta expressed in baculovirus-infected sf21 cells using PI(4,5)P2 as substrate after 15 mins by HT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM60631(BDBM50447096 | US9133168, 19b)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal ploy-His-tagged human PI3Kgamma expressed in baculovirus-infected sf9 cells using PI(4,5)P2 as substrate after 15 mins by HT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed