BDBM603967 2-(3′-(hydroxymethyl)-1-methyl-6-oxo-5-((5-((2S,6S)-2,4,6-trimethylpiperazin-1-yl)pyridin-2-yl)amino)-1,6-dihydro-[3,4′-bipyridin]-2′-yl)-7,7-dimethyl-7,8-dihydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one::US11655254, Compound 6::US20230382916, Compound 6

SMILES C[C@H]1CN(C)C[C@H](C)N1c1ccc(Nc2cc(cn(C)c2=O)-c2ccnc(c2CO)-n2ccn3c4CC(C)(C)Cc4cc3c2=O)nc1

InChI Key InChIKey=VRAFWAYZAJAILV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 603967   

TargetTyrosine-protein kinase BTK(Human)
Hutchison Medipharma

US Patent
LigandPNGBDBM603967(US11655254, Compound 6 | 2-(3′-(hydroxymethy...)
Affinity DataIC50: 7nMAssay Description:1. Reagents and Materials: BTK recombinant protein: Invitrogen, Cat #PV3363;Z′-LYTE kinase test kit-tyrosine 1 peptide: Invitrogen, Cat #PV3190...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Hutchison Medipharma

US Patent
LigandPNGBDBM603967(US11655254, Compound 6 | 2-(3′-(hydroxymethy...)
Affinity DataIC50: 7nMAssay Description:Z′-LYTE biochemical assay employs a fluorescence resonance energy transfer (FRET)-based, coupled-enzyme format and is based on the differential...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent