BDBM602181 US11643436, Compound TM-2A

SMILES CC(C)C[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1ccccc1)C(=O)N[C@H](CCCCN)C(=O)N1CC[C@H](C1)B(O)O

InChI Key InChIKey=ZXPSSCMDSWBRDR-UHFFFAOYSA-N

Data  5 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 602181   

TargetKappa-type opioid receptor(Human)
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM602181(US11643436, Compound TM-2A)
Affinity DataEC50:  0.0330nMAssay Description:Forskolin can stimulate the release of cAMP from HEK293 cells with high expression of human κ (or μ, or δ)-opioid receptors. The κ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
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TargetDelta-type opioid receptor(Human)
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM602181(US11643436, Compound TM-2A)
Affinity DataEC50: >1.00E+4nMAssay Description:Forskolin can stimulate the release of cAMP from HEK293 cells with high expression of human κ (or μ, or δ)-opioid receptors. The κ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent

TargetMu-type opioid receptor(Human)
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM602181(US11643436, Compound TM-2A)
Affinity DataEC50: >1.00E+4nMAssay Description:Forskolin can stimulate the release of cAMP from HEK293 cells with high expression of human κ (or μ, or δ)-opioid receptors. The κ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent

TargetCytochrome P450 1A2(Human)
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM602181(US11643436, Compound TM-2A)
Affinity DataIC50: 5.00E+4nMAssay Description:The human liver microsomes (0.253 mg/mL protein) containing cytochrome P450, test compounds (0.05-50 μM), CYPs substrates (10 μM p-acetamin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
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TargetCytochrome P450 2D6(Human)
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM602181(US11643436, Compound TM-2A)
Affinity DataIC50: 5.00E+4nMAssay Description:The human liver microsomes (0.253 mg/mL protein) containing cytochrome P450, test compounds (0.05-50 μM), CYPs substrates (10 μM p-acetamin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM602181(US11643436, Compound TM-2A)
Affinity DataIC50: 5.00E+4nMAssay Description:The human liver microsomes (0.253 mg/mL protein) containing cytochrome P450, test compounds (0.05-50 μM), CYPs substrates (10 μM p-acetamin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent

TargetCytochrome P450 2C9(Human)
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM602181(US11643436, Compound TM-2A)
Affinity DataIC50: 5.00E+4nMAssay Description:The human liver microsomes (0.253 mg/mL protein) containing cytochrome P450, test compounds (0.05-50 μM), CYPs substrates (10 μM p-acetamin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent

TargetCytochrome P450 2C19(Human)
Chengdu Sintanovo Biotechnology

US Patent
LigandPNGBDBM602181(US11643436, Compound TM-2A)
Affinity DataIC50: 5.00E+4nMAssay Description:The human liver microsomes (0.253 mg/mL protein) containing cytochrome P450, test compounds (0.05-50 μM), CYPs substrates (10 μM p-acetamin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent