BDBM601942 4-((8'-methyl-7'-oxo-7',8'-dihydro- 6'H-spiro[cyclohexane-1,9'- pyrrolo[1,5-a:2,3-d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US11643416, Compound 42::US20240150369, Compound 42

SMILES CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1

InChI Key InChIKey=KJHOORCYJSBANN-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 601942   

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601942(US11643416, Compound 42 | 4-((8'-methyl-7'-oxo-7',...)
Affinity DataIC50: 1nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
Go to US Patent

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601942(US11643416, Compound 42 | 4-((8'-methyl-7'-oxo-7',...)
Affinity DataIC50: 83nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 5 activator 1(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601942(US11643416, Compound 42 | 4-((8'-methyl-7'-oxo-7',...)
Affinity DataIC50: 2nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
Go to US Patent

Targetcdk3cyclin-e(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601942(US11643416, Compound 42 | 4-((8'-methyl-7'-oxo-7',...)
Affinity DataIC50: 10nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
Go to US Patent

TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601942(US11643416, Compound 42 | 4-((8'-methyl-7'-oxo-7',...)
Affinity DataIC50: 7nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
Go to US Patent

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601942(US11643416, Compound 42 | 4-((8'-methyl-7'-oxo-7',...)
Affinity DataIC50: 6nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601942(US11643416, Compound 42 | 4-((8'-methyl-7'-oxo-7',...)
Affinity DataIC50: 147nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601942(US11643416, Compound 42 | 4-((8'-methyl-7'-oxo-7',...)
Affinity DataIC50: 57nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601942(US11643416, Compound 42 | 4-((8'-methyl-7'-oxo-7',...)
Affinity DataIC50: 1nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
Go to US Patent

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601942(US11643416, Compound 42 | 4-((8'-methyl-7'-oxo-7',...)
Affinity DataIC50: 1nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 7(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601942(US11643416, Compound 42 | 4-((8'-methyl-7'-oxo-7',...)
Affinity DataIC50: 83nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 5 activator 1(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601942(US11643416, Compound 42 | 4-((8'-methyl-7'-oxo-7',...)
Affinity DataIC50: 2nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent

Targetcdk3cyclin-e(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601942(US11643416, Compound 42 | 4-((8'-methyl-7'-oxo-7',...)
Affinity DataIC50: 10nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 1(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601942(US11643416, Compound 42 | 4-((8'-methyl-7'-oxo-7',...)
Affinity DataIC50: 7nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601942(US11643416, Compound 42 | 4-((8'-methyl-7'-oxo-7',...)
Affinity DataIC50: 6nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601942(US11643416, Compound 42 | 4-((8'-methyl-7'-oxo-7',...)
Affinity DataIC50: 147nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601942(US11643416, Compound 42 | 4-((8'-methyl-7'-oxo-7',...)
Affinity DataIC50: 57nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
G1 Therapeutics

US Patent
LigandPNGBDBM601942(US11643416, Compound 42 | 4-((8'-methyl-7'-oxo-7',...)
Affinity DataIC50: 1nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2023
Entry Details
Go to US Patent