BDBM601941 (S)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1'2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US11643416, Compound 23::US20240150369, Compound 23

SMILES NS(=O)(=O)c1ccc(Nc2ncc3cc4[C@@H](CF)NC(=O)C5(CCCCC5)n4c3n2)cc1

InChI Key InChIKey=FKAJEPVSQITQLJ-UHFFFAOYSA-N

Data  18 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 601941   

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
G1 Therapeutics

US Patent

LigandBDBM601941(US11643416, Compound 23 | (S)-4-((6'-(fluoromethyl...)Copy SMILESCopy InChI

Affinity DataIC50: 1nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
8/9/2024
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TargetCyclin-H/Cyclin-dependent kinase 7(Human)
G1 Therapeutics

US Patent

LigandBDBM601941(US11643416, Compound 23 | (S)-4-((6'-(fluoromethyl...)Copy SMILESCopy InChI

Affinity DataIC50: 682nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
8/9/2024
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TargetCyclin-dependent kinase 5 activator 1(Human)
G1 Therapeutics

US Patent

LigandBDBM601941(US11643416, Compound 23 | (S)-4-((6'-(fluoromethyl...)Copy SMILESCopy InChI

Affinity DataIC50: 12nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
8/9/2024
Entry Details
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Targetcdk3cyclin-e(Human)
G1 Therapeutics

US Patent

LigandBDBM601941(US11643416, Compound 23 | (S)-4-((6'-(fluoromethyl...)Copy SMILESCopy InChI

Affinity DataIC50: 6nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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Date in BDB:
8/9/2024
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TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
G1 Therapeutics

US Patent

LigandBDBM601941(US11643416, Compound 23 | (S)-4-((6'-(fluoromethyl...)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

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Date in BDB:
8/9/2024
Entry Details
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TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
G1 Therapeutics

US Patent

LigandBDBM601941(US11643416, Compound 23 | (S)-4-((6'-(fluoromethyl...)Copy SMILESCopy InChI

Affinity DataIC50: 11nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

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Date in BDB:
8/9/2024
Entry Details
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TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
G1 Therapeutics

US Patent

LigandBDBM601941(US11643416, Compound 23 | (S)-4-((6'-(fluoromethyl...)Copy SMILESCopy InChI

Affinity DataIC50: 45nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/9/2024
Entry Details
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TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
G1 Therapeutics

US Patent

LigandBDBM601941(US11643416, Compound 23 | (S)-4-((6'-(fluoromethyl...)Copy SMILESCopy InChI

Affinity DataIC50: 19nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

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Date in BDB:
8/9/2024
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TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
G1 Therapeutics

US Patent

LigandBDBM601941(US11643416, Compound 23 | (S)-4-((6'-(fluoromethyl...)Copy SMILESCopy InChI

Affinity DataIC50: 1nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/9/2024
Entry Details
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TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
G1 Therapeutics

US Patent

LigandBDBM601941(US11643416, Compound 23 | (S)-4-((6'-(fluoromethyl...)Copy SMILESCopy InChI

Affinity DataIC50: 1nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/11/2023
Entry Details
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TargetCyclin-dependent kinase 7(Human)
G1 Therapeutics

US Patent

LigandBDBM601941(US11643416, Compound 23 | (S)-4-((6'-(fluoromethyl...)Copy SMILESCopy InChI

Affinity DataIC50: 682nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/11/2023
Entry Details
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TargetCyclin-dependent kinase 5 activator 1(Human)
G1 Therapeutics

US Patent

LigandBDBM601941(US11643416, Compound 23 | (S)-4-((6'-(fluoromethyl...)Copy SMILESCopy InChI

Affinity DataIC50: 12nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/11/2023
Entry Details
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Targetcdk3cyclin-e(Human)
G1 Therapeutics

US Patent

LigandBDBM601941(US11643416, Compound 23 | (S)-4-((6'-(fluoromethyl...)Copy SMILESCopy InChI

Affinity DataIC50: 6nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
6/11/2023
Entry Details
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TargetCyclin-dependent kinase 1(Human)
G1 Therapeutics

US Patent

LigandBDBM601941(US11643416, Compound 23 | (S)-4-((6'-(fluoromethyl...)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/11/2023
Entry Details
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TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
G1 Therapeutics

US Patent

LigandBDBM601941(US11643416, Compound 23 | (S)-4-((6'-(fluoromethyl...)Copy SMILESCopy InChI

Affinity DataIC50: 11nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/11/2023
Entry Details
Copy Entry DOIGo to US Patent

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TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
G1 Therapeutics

US Patent

LigandBDBM601941(US11643416, Compound 23 | (S)-4-((6'-(fluoromethyl...)Copy SMILESCopy InChI

Affinity DataIC50: 45nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/11/2023
Entry Details
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TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
G1 Therapeutics

US Patent

LigandBDBM601941(US11643416, Compound 23 | (S)-4-((6'-(fluoromethyl...)Copy SMILESCopy InChI

Affinity DataIC50: 19nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/11/2023
Entry Details
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TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
G1 Therapeutics

US Patent

LigandBDBM601941(US11643416, Compound 23 | (S)-4-((6'-(fluoromethyl...)Copy SMILESCopy InChI

Affinity DataIC50: 1nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/11/2023
Entry Details
Copy Entry DOIGo to US Patent

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