BDBM601933 4-((6'-hydroxy-8'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]- 2'-yl)amino)benzenesulfonamide::US11643416, Compound 1::US20240150369, Compound 1

SMILES NS(=O)(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1

InChI Key InChIKey=DQBASRYERZQRJJ-UHFFFAOYSA-N

Data  20 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 601933   

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
G1 Therapeutics

US Patent

LigandBDBM601933(US11643416, Compound 1 | 4-((6'-hydroxy-8'-oxo-7',...)Copy SMILESCopy InChI

Affinity DataIC50: 0.160nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

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TargetCyclin-H/Cyclin-dependent kinase 7(Human)
G1 Therapeutics

US Patent

LigandBDBM601933(US11643416, Compound 1 | 4-((6'-hydroxy-8'-oxo-7',...)Copy SMILESCopy InChI

Affinity DataIC50: 560nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

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TargetCyclin-dependent kinase 5 activator 1(Human)
G1 Therapeutics

US Patent

LigandBDBM601933(US11643416, Compound 1 | 4-((6'-hydroxy-8'-oxo-7',...)Copy SMILESCopy InChI

Affinity DataIC50: 0.800nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

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TargetCyclin-dependent kinase 5 activator 1(Human)
G1 Therapeutics

US Patent

LigandBDBM601933(US11643416, Compound 1 | 4-((6'-hydroxy-8'-oxo-7',...)Copy SMILESCopy InChI

Affinity DataIC50: 0.680nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

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Targetcdk3cyclin-e(Human)
G1 Therapeutics

US Patent

LigandBDBM601933(US11643416, Compound 1 | 4-((6'-hydroxy-8'-oxo-7',...)Copy SMILESCopy InChI

Affinity DataIC50: 0.940nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

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TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
G1 Therapeutics

US Patent

LigandBDBM601933(US11643416, Compound 1 | 4-((6'-hydroxy-8'-oxo-7',...)Copy SMILESCopy InChI

Affinity DataIC50: 2.20nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

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TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
G1 Therapeutics

US Patent

LigandBDBM601933(US11643416, Compound 1 | 4-((6'-hydroxy-8'-oxo-7',...)Copy SMILESCopy InChI

Affinity DataIC50: 1.40nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

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TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
G1 Therapeutics

US Patent

LigandBDBM601933(US11643416, Compound 1 | 4-((6'-hydroxy-8'-oxo-7',...)Copy SMILESCopy InChI

Affinity DataIC50: 7.5nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

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TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
G1 Therapeutics

US Patent

LigandBDBM601933(US11643416, Compound 1 | 4-((6'-hydroxy-8'-oxo-7',...)Copy SMILESCopy InChI

Affinity DataIC50: 3.10nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

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TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
G1 Therapeutics

US Patent

LigandBDBM601933(US11643416, Compound 1 | 4-((6'-hydroxy-8'-oxo-7',...)Copy SMILESCopy InChI

Affinity DataIC50: 0.340nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, CA) to determine their inhibitory effect on these CDKs. The...More data for this Ligand-Target Pair

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TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
G1 Therapeutics

US Patent

LigandBDBM601933(US11643416, Compound 1 | 4-((6'-hydroxy-8'-oxo-7',...)Copy SMILESCopy InChI

Affinity DataIC50: 0.160nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

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TargetCyclin-dependent kinase 7(Human)
G1 Therapeutics

US Patent

LigandBDBM601933(US11643416, Compound 1 | 4-((6'-hydroxy-8'-oxo-7',...)Copy SMILESCopy InChI

Affinity DataIC50: 560nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

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TargetCyclin-dependent kinase 5 activator 1 [99-307](Human)
G1 Therapeutics

US Patent

LigandBDBM601933(US11643416, Compound 1 | 4-((6'-hydroxy-8'-oxo-7',...)Copy SMILESCopy InChI

Affinity DataIC50: 0.800nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

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TargetCyclin-dependent kinase 5 activator 1(Human)
G1 Therapeutics

US Patent

LigandBDBM601933(US11643416, Compound 1 | 4-((6'-hydroxy-8'-oxo-7',...)Copy SMILESCopy InChI

Affinity DataIC50: 0.680nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

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Targetcdk3cyclin-e(Human)
G1 Therapeutics

US Patent

LigandBDBM601933(US11643416, Compound 1 | 4-((6'-hydroxy-8'-oxo-7',...)Copy SMILESCopy InChI

Affinity DataIC50: 0.940nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

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TargetCyclin-dependent kinase 1(Human)
G1 Therapeutics

US Patent

LigandBDBM601933(US11643416, Compound 1 | 4-((6'-hydroxy-8'-oxo-7',...)Copy SMILESCopy InChI

Affinity DataIC50: 2.20nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

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TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
G1 Therapeutics

US Patent

LigandBDBM601933(US11643416, Compound 1 | 4-((6'-hydroxy-8'-oxo-7',...)Copy SMILESCopy InChI

Affinity DataIC50: 1.40nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

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TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
G1 Therapeutics

US Patent

LigandBDBM601933(US11643416, Compound 1 | 4-((6'-hydroxy-8'-oxo-7',...)Copy SMILESCopy InChI

Affinity DataIC50: 7.5nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

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TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
G1 Therapeutics

US Patent

LigandBDBM601933(US11643416, Compound 1 | 4-((6'-hydroxy-8'-oxo-7',...)Copy SMILESCopy InChI

Affinity DataIC50: 3.10nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

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TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
G1 Therapeutics

US Patent

LigandBDBM601933(US11643416, Compound 1 | 4-((6'-hydroxy-8'-oxo-7',...)Copy SMILESCopy InChI

Affinity DataIC50: 0.340nMAssay Description:Selected compounds disclosed herein were tested in kinase assays by Nanosyn (Santa Clara, Calif.) to determine their inhibitory effect on these CDKs....More data for this Ligand-Target Pair

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