BDBM597671 5-(5-cyclopropylisoxazol-3- yl)-7-(oxetan-3-yl)-7H- pyrrolo[2,3-d]pyrimidin-4- amine::US11603374, Example 26

SMILES Nc1ncnc2n(cc(-c3cc(on3)C3CC3)c12)C1COC1

InChI Key InChIKey=TXBBYTSVSXMIOO-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 597671   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM597671(5-(5-cyclopropylisoxazol-3- yl)-7-(oxetan-3-yl)-7H...)
Affinity DataIC50: 2.30nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
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LigandPNGBDBM597671(5-(5-cyclopropylisoxazol-3- yl)-7-(oxetan-3-yl)-7H...)
Affinity DataIC50: 12.9nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
Go to US Patent

LigandPNGBDBM597671(5-(5-cyclopropylisoxazol-3- yl)-7-(oxetan-3-yl)-7H...)
Affinity DataIC50: 2.30nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
Go to US Patent

LigandPNGBDBM597671(5-(5-cyclopropylisoxazol-3- yl)-7-(oxetan-3-yl)-7H...)
Affinity DataIC50: 27.7nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
Go to US Patent

LigandPNGBDBM597671(5-(5-cyclopropylisoxazol-3- yl)-7-(oxetan-3-yl)-7H...)
Affinity DataIC50: 9.70nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
Go to US Patent