BDBM597646 US11603374, Example 1

SMILES CC(C)n1cc(-c2noc(C3CC3)c2I)c2c(N)ncnc12

InChI Key InChIKey=COYZCPQMGQEXFJ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 597646   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM597646(US11603374, Example 1)
Affinity DataIC50: 0.5nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
Go to US Patent

LigandPNGBDBM597646(US11603374, Example 1)
Affinity DataIC50: 1.40nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
Go to US Patent

LigandPNGBDBM597646(US11603374, Example 1)
Affinity DataIC50: 0.5nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
Go to US Patent

LigandPNGBDBM597646(US11603374, Example 1)
Affinity DataIC50: 2.10nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
Go to US Patent

LigandPNGBDBM597646(US11603374, Example 1)
Affinity DataIC50: 2.5nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
Go to US Patent