BDBM594035 Synthesis of (R,E)-2-(11,11-difluoro-3-hydroxy-3,7-dimethylundeca-6,10-dien-1-yl)-3,5,6-trimethylcyclohexa-2,5-diene-1,4-dione ::US11584728, Compound H::US12049455, Compound H::US20230303506, Compound H

SMILES [#6]\[#6](-[#6]-[#6]\[#6]=[#6](\F)F)=[#6]/[#6]-[#6][C@@]([#6])([#8])[#6]-[#6]-[#6]-1=[#6](-[#6])-[#6](=O)-[#6](-[#6])=[#6](-[#6])-[#6]-1=O

InChI Key InChIKey=XKEASTLGLKSSPF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 594035   

TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Stealth Biotherapeutics

US Patent
LigandPNGBDBM594035(US11584728, Compound H | Synthesis of (R,E)-2-(11,...)
Affinity DataIC50: 2.93E+3nMAssay Description:Briefly, reactions were carried out in Corning 96 half-well black, flat bottom assay plates and contained final concentrations of 50 μM arachido...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
Go to US Patent

TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Stealth Biotherapeutics

US Patent
LigandPNGBDBM594035(US11584728, Compound H | Synthesis of (R,E)-2-(11,...)
Affinity DataIC50: 2.93E+3nMAssay Description:Briefly, reactions were carried out in Corning 96 half-well black, flat bottom assay plates and contained final concentrations of 50 μM arachido...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
Go to US Patent

TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Stealth Biotherapeutics

US Patent
LigandPNGBDBM594035(US11584728, Compound H | Synthesis of (R,E)-2-(11,...)
Affinity DataIC50: 2.93E+3nMAssay Description:Briefly, reactions were carried out in Corning 96 half-well black, flat bottom assay plates and contained final concentrations of 50 μM arachido...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2024
Entry Details
Go to US Patent

TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Human)
Stealth Biotherapeutics

US Patent
LigandPNGBDBM594035(US11584728, Compound H | Synthesis of (R,E)-2-(11,...)
Affinity DataIC50: 2.93E+3nMAssay Description:Briefly, reactions were carried out in Corning 96 half-well black, flat bottom assay plates and contained final concentrations of 50 μM arachido...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2024
Entry Details
Go to US Patent