BDBM591644 US11566007, Example A323

SMILES CCn1c(c2CC(C)(C)COC(=O)[C@@H]3CCCN(N3)C(=O)[C@H](Cc3nc(cs3)-c3ccc1c2c3)NC(=O)[C@H](C(C)C)N1CCC2(CN(C2)C(=O)C#CC(C)(C)N(C)C)C1=O)-c1cccnc1[C@H](C)OC

InChI Key InChIKey=UYOYMXSYXDVXIC-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 591644   

TargetGTPase KRas [G13C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591644(US11566007, Example A323)
Affinity DataIC50: 550nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGTPase KRas [G13D](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591644(US11566007, Example A323)
Affinity DataIC50: 1.00E+4nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGTPase KRas [G12V](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591644(US11566007, Example A323)
Affinity DataIC50: 1.00E+4nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591644(US11566007, Example A323)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGTPase KRas [G12S](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591644(US11566007, Example A323)
Affinity DataIC50: 1.00E+4nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGTPase KRas(Human)
Revolution Medicines

US Patent
LigandPNGBDBM591644(US11566007, Example A323)
Affinity DataIC50: 1.00E+4nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGTPase KRas [G12D](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591644(US11566007, Example A323)
Affinity DataIC50: 1.00E+4nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetGTPase KRas [G12C](Human)
Revolution Medicines

US Patent
LigandPNGBDBM591644(US11566007, Example A323)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In DepthDetails
US Patent