BDBM59087 CHEMBL258765::Fasca-plysi::Fascaplysin

SMILES O=C1c2ccccc2-[n+]2ccc3c([nH]c4ccccc34)c12

InChI Key InChIKey=WYQIPCUPNMRAKP-UHFFFAOYSA-O

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 59087   

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM59087(CHEMBL258765 | Fascaplysin | Fasca-plysi)
Affinity DataIC50: 2.50E+5nMAssay Description:Binding affinity to human CDK2/cyclinA using GST-pRB152 as substrate by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetCholinesterase(Human)
Univ. Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM59087(CHEMBL258765 | Fascaplysin | Fasca-plysi)
Affinity DataIC50: 9.00E+4nMAssay Description:Inhibition of BuChE (unknown origin) using acetylthiocholine iodide as substrate incubated for 20 mins followed by substrate addition by Ellman's met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Univ. Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM59087(CHEMBL258765 | Fascaplysin | Fasca-plysi)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate incubated for 20 mins followed by substrate addition by Ellman's meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Michigan State University

LigandPNGBDBM59087(CHEMBL258765 | Fascaplysin | Fasca-plysi)
Affinity DataIC50: 9.96E+3nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2022
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Michigan State University

LigandPNGBDBM59087(CHEMBL258765 | Fascaplysin | Fasca-plysi)
Affinity DataIC50: 9.96E+3nMAssay Description:The 3CLpro enzyme assay was developed in 384-well black, medium binding microplates (Greiner Bio-One, Monroe, NC, USA) with a total volume of 20 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM59087(CHEMBL258765 | Fascaplysin | Fasca-plysi)
Affinity DataIC50: 350nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM59087(CHEMBL258765 | Fascaplysin | Fasca-plysi)
Affinity DataIC50: 2.50E+5nMAssay Description:Binding affinity to human CDK9/cyclinT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM59087(CHEMBL258765 | Fascaplysin | Fasca-plysi)
Affinity DataIC50: 2.50E+5nMAssay Description:Binding affinity to human CDK1/cyclinB1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM59087(CHEMBL258765 | Fascaplysin | Fasca-plysi)
Affinity DataIC50: 2.50E+5nMAssay Description:Binding affinity to human CDK2/cyclinEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM59087(CHEMBL258765 | Fascaplysin | Fasca-plysi)
Affinity DataIC50: 350nMAssay Description:In vitro kinase inhibition assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2011
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
De Montfort University

Curated by ChEMBL
LigandPNGBDBM59087(CHEMBL258765 | Fascaplysin | Fasca-plysi)
Affinity DataIC50: 410nMAssay Description:Binding affinity to human CDK4/cyclinD1 using GST-pRB152 as substrate by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
University of Leicester

Curated by ChEMBL
LigandPNGBDBM59087(CHEMBL258765 | Fascaplysin | Fasca-plysi)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of human CDK2/ Cyclin A catalytic subunit expressed in Sf9 insect cells assessed as histone H1 phosphorylation-associated depletion in ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM59087(CHEMBL258765 | Fascaplysin | Fasca-plysi)
Affinity DataIC50: 550nMAssay Description:Inhibition of human CDK4/ Cyclin D1 catalytic subunit expressed in Sf9 insect cells assessed as GST-RB152 fusion protein phosphorylation-associated d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
University of Leicester

Curated by ChEMBL
LigandPNGBDBM59087(CHEMBL258765 | Fascaplysin | Fasca-plysi)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of human CDK2/GST-cyclin A expressed in Sf9 cells assessed as histone phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM59087(CHEMBL258765 | Fascaplysin | Fasca-plysi)
Affinity DataIC50: 550nMAssay Description:Inhibition of human CDK4/GST-cyclin D1 expressed in Sf9 cells assessed as retinoblastoma GST-RB152 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 6(Human)
Griffith University

Curated by ChEMBL
LigandPNGBDBM59087(CHEMBL258765 | Fascaplysin | Fasca-plysi)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of CDK6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM59087(CHEMBL258765 | Fascaplysin | Fasca-plysi)
Affinity DataIC50: 350nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
University of Leicester

Curated by ChEMBL
LigandPNGBDBM59087(CHEMBL258765 | Fascaplysin | Fasca-plysi)
Affinity DataIC50: 5.00E+4nMAssay Description:In vitro kinase inhibition assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2011
Entry Details Article
PubMed