BDBM590744 US11564920, Example 28

SMILES COc1cncc(OC[C@H](C)CN)c1-c1cc(Nc2cnc(cn2)C#N)n[nH]1

InChI Key InChIKey=YRHQDDRNFFJEKC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 590744   

TargetSerine/threonine-protein kinase Chk1(Human)
Sumitomo Pharma

US Patent
LigandPNGBDBM590744(US11564920, Example 28)
Affinity DataIC50: 0.800nMAssay Description:IMAP TR-FRET Screening Express Kit (R8160) was obtained from Molecular Devices. CHK1 kinase (02-117, Carna Bio), FAM-labeled CHK1tide (R7185, Molecul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
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TargetPotassium voltage-gated channel subfamily H member 2(Human)
Sumitomo Pharma

US Patent
LigandPNGBDBM590744(US11564920, Example 28)
Affinity DataIC50: 1.67E+4nMAssay Description:The test compounds were added to cultured hERG (human Ether-a-go-go Related Gene) gene stably expressing CHO cell line cells to achieve 0.27 to 100 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
Go to US Patent