BDBM5844 3-{4-[(2-{[4-(methanesulfonylmethyl)phenyl]amino}pyrimidin-4-yl)(methyl)amino]phenyl}-1-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}urea::D3RKN_88::urea deriv. 35

SMILES CN(c1ccc(NC(=O)Nc2ccc(CN3CCN(C)CC3)cc2)cc1)c1ccnc(Nc2ccc(CS(C)(=O)=O)cc2)n1

InChI Key InChIKey=WUUXQSKAAWHECK-UHFFFAOYSA-N

Data  1 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 5844   

LigandPNGBDBM5844(3-{4-[(2-{[4-(methanesulfonylmethyl)phenyl]amino}p...)
Affinity DataIC50: 4nMpH: 7.5 T: 2°CAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2005
Entry Details Article
PubMed
LigandPNGBDBM5844(3-{4-[(2-{[4-(methanesulfonylmethyl)phenyl]amino}p...)
Affinity DataKd:  2.30nMAssay Description:D3R2021More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2023
Entry Details
D3R

TargetTyrosine-protein kinase JAK2(Human)
D3R/Abbott

LigandPNGBDBM5844(3-{4-[(2-{[4-(methanesulfonylmethyl)phenyl]amino}p...)
Affinity DataKd:  42nMAssay Description:D3R2022More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2023
Entry Details
D3R

LigandPNGBDBM5844(3-{4-[(2-{[4-(methanesulfonylmethyl)phenyl]amino}p...)
Affinity DataKd:  1.00E+4nMAssay Description:D3R2023More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2023
Entry Details
D3R