BDBM580927 5-(4-((2-chlorophenyl)sulfonyl)-6- morpholinopyridin-2-yl)pyrimidin-2-amine::US11492348, Compound 139

SMILES Nc1ncc(cn1)-c1cc(cc(n1)N1CCOCC1)S(=O)(=O)c1ccccc1Cl

InChI Key InChIKey=JTYJEIBZRLYYQC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 580927   

LigandPNGBDBM580927(US11492348, Compound 139 | 5-(4-((2-chlorophenyl)s...)
Affinity DataIC50: 17nMAssay Description:Quantification of ATP to ADP conversion as a measure of PI3Kα activity. Active PI3Kα (Life Technologies), in the presence or absence of PI3...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRAC-alpha serine/threonine-protein kinase [1-472,474-480](Human)
Neuropore Therapies

US Patent
LigandPNGBDBM580927(US11492348, Compound 139 | 5-(4-((2-chlorophenyl)s...)
Affinity DataIC50: 16nMAssay Description:Inhibition of the PI3K-AKT-mTOR pathway was measured by quantifying the loss of (Ser-473) pAKT using AlphaScreen (Perkin Elmer). B103 (Rat Neuroblast...More data for this Ligand-Target Pair
In DepthDetails
US Patent