BDBM580925 5-(6-morpholino-4-(o-tolyloxy)pyridin-2- yl)pyrimidin-2-amine::US11492348, Compound 137

SMILES Cc1ccccc1Oc1cc(nc(c1)-c1cnc(N)nc1)N1CCOCC1

InChI Key InChIKey=STGMRFRVEBSQDM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 580925   

LigandPNGBDBM580925(US11492348, Compound 137 | 5-(6-morpholino-4-(o-to...)
Affinity DataIC50: 75nMAssay Description:Quantification of ATP to ADP conversion as a measure of PI3Kα activity. Active PI3Kα (Life Technologies), in the presence or absence of PI3...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRAC-alpha serine/threonine-protein kinase [1-472,474-480](Human)
Neuropore Therapies

US Patent
LigandPNGBDBM580925(US11492348, Compound 137 | 5-(6-morpholino-4-(o-to...)
Affinity DataIC50: 450nMAssay Description:Inhibition of the PI3K-AKT-mTOR pathway was measured by quantifying the loss of (Ser-473) pAKT using AlphaScreen (Perkin Elmer). B103 (Rat Neuroblast...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Neuropore Therapies

US Patent
LigandPNGBDBM580925(US11492348, Compound 137 | 5-(6-morpholino-4-(o-to...)
Affinity DataIC50: 370nMAssay Description:The substrate was prepared in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM D...More data for this Ligand-Target Pair
In DepthDetails
US Patent