BDBM580890 US11492348, Compound 102::cyclopropyl(3-((3-(2- (cyclopropylamino)pyrimidin-5-yl)-5- morpholinophenyl)sulfonyl)azetidin-1- yl)methanone

SMILES O=C(C1CC1)N1CC(C1)S(=O)(=O)c1cc(cc(c1)-c1cnc(NC2CC2)nc1)N1CCOCC1

InChI Key InChIKey=PVGCVDXYYMLKTI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 580890   

LigandPNGBDBM580890(US11492348, Compound 102 | cyclopropyl(3-((3-(2- (...)
Affinity DataIC50: 540nMAssay Description:Quantification of ATP to ADP conversion as a measure of PI3Kα activity. Active PI3Kα (Life Technologies), in the presence or absence of PI3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
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TargetRAC-alpha serine/threonine-protein kinase [1-472,474-480](Human)
Neuropore Therapies

US Patent
LigandPNGBDBM580890(US11492348, Compound 102 | cyclopropyl(3-((3-(2- (...)
Affinity DataIC50: 6.79E+3nMAssay Description:Inhibition of the PI3K-AKT-mTOR pathway was measured by quantifying the loss of (Ser-473) pAKT using AlphaScreen (Perkin Elmer). B103 (Rat Neuroblast...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
Go to US Patent