BDBM580881 3-((3-(2-aminopyrimidin-5-yl)-5- morpholinophenyl)sulfonyl)-N- ethylazetidine-1-carboxamide::US11492348, Compound 93

SMILES CCNC(=O)N1CC(C1)S(=O)(=O)c1cc(cc(c1)-c1cnc(N)nc1)N1CCOCC1

InChI Key InChIKey=RBTWNXQTOCPFLO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 580881   

LigandPNGBDBM580881(US11492348, Compound 93 | 3-((3-(2-aminopyrimidin-...)
Affinity DataIC50: 88nMAssay Description:Quantification of ATP to ADP conversion as a measure of PI3Kα activity. Active PI3Kα (Life Technologies), in the presence or absence of PI3...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRAC-alpha serine/threonine-protein kinase [1-472,474-480](Human)
Neuropore Therapies

US Patent
LigandPNGBDBM580881(US11492348, Compound 93 | 3-((3-(2-aminopyrimidin-...)
Affinity DataIC50: 5.44E+3nMAssay Description:Inhibition of the PI3K-AKT-mTOR pathway was measured by quantifying the loss of (Ser-473) pAKT using AlphaScreen (Perkin Elmer). B103 (Rat Neuroblast...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Neuropore Therapies

US Patent
LigandPNGBDBM580881(US11492348, Compound 93 | 3-((3-(2-aminopyrimidin-...)
Affinity DataIC50: 870nMAssay Description:The substrate was prepared in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM D...More data for this Ligand-Target Pair
In DepthDetails
US Patent