BDBM580879 1-(3-((3-(2-aminopyrimidin-5-yl)-5- morpholinophenyl)sulfonyl)pyrrolidin-1- yl)ethan-1-one::US11492348, Compound 91

SMILES CC(=O)N1CCC(C1)S(=O)(=O)c1cc(cc(c1)-c1cnc(N)nc1)N1CCOCC1

InChI Key InChIKey=YMNYQOBKIRPWSR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 580879   

LigandPNGBDBM580879(US11492348, Compound 91 | 1-(3-((3-(2-aminopyrimid...)
Affinity DataIC50: 180nMAssay Description:Quantification of ATP to ADP conversion as a measure of PI3Kα activity. Active PI3Kα (Life Technologies), in the presence or absence of PI3...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRAC-alpha serine/threonine-protein kinase [1-472,474-480](Human)
Neuropore Therapies

US Patent
LigandPNGBDBM580879(US11492348, Compound 91 | 1-(3-((3-(2-aminopyrimid...)
Affinity DataIC50: 7.33E+3nMAssay Description:Inhibition of the PI3K-AKT-mTOR pathway was measured by quantifying the loss of (Ser-473) pAKT using AlphaScreen (Perkin Elmer). B103 (Rat Neuroblast...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Neuropore Therapies

US Patent
LigandPNGBDBM580879(US11492348, Compound 91 | 1-(3-((3-(2-aminopyrimid...)
Affinity DataIC50: 2.58E+3nMAssay Description:The substrate was prepared in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM D...More data for this Ligand-Target Pair
In DepthDetails
US Patent