BDBM580866 1-(3-((3-(2-aminopyrimidin-5-yl)-5- morpholinophenyl)sulfonyl)azetidin-1-yl)-2- (4-fluorophenyl)ethan-1-one::US11492348, Compound 78

SMILES Nc1ncc(cn1)-c1cc(cc(c1)S(=O)(=O)C1CN(C1)C(=O)Cc1ccc(F)cc1)N1CCOCC1

InChI Key InChIKey=BKEZTGYVYYPAKU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 580866   

LigandPNGBDBM580866(US11492348, Compound 78 | 1-(3-((3-(2-aminopyrimid...)
Affinity DataIC50: 180nMAssay Description:Quantification of ATP to ADP conversion as a measure of PI3Kα activity. Active PI3Kα (Life Technologies), in the presence or absence of PI3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
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TargetRAC-alpha serine/threonine-protein kinase [1-472,474-480](Human)
Neuropore Therapies

US Patent
LigandPNGBDBM580866(US11492348, Compound 78 | 1-(3-((3-(2-aminopyrimid...)
Affinity DataIC50: 4.52E+3nMAssay Description:Inhibition of the PI3K-AKT-mTOR pathway was measured by quantifying the loss of (Ser-473) pAKT using AlphaScreen (Perkin Elmer). B103 (Rat Neuroblast...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
Go to US Patent