BDBM580820 5-(3-(benzylsulfonyl)-5-morpholinophenyl)- 4-(trifluoromethyl)pyridin-2-amine::US11492348, Compound 32

SMILES Nc1cc(c(cn1)-c1cc(cc(c1)S(=O)(=O)Cc1ccccc1)N1CCOCC1)C(F)(F)F

InChI Key InChIKey=LVHZEQFUPUPOLU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 580820   

LigandPNGBDBM580820(US11492348, Compound 32 | 5-(3-(benzylsulfonyl)-5-...)
Affinity DataIC50: 450nMAssay Description:Quantification of ATP to ADP conversion as a measure of PI3Kα activity. Active PI3Kα (Life Technologies), in the presence or absence of PI3...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetRAC-alpha serine/threonine-protein kinase [1-472,474-480](Human)
Neuropore Therapies

US Patent
LigandPNGBDBM580820(US11492348, Compound 32 | 5-(3-(benzylsulfonyl)-5-...)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of the PI3K-AKT-mTOR pathway was measured by quantifying the loss of (Ser-473) pAKT using AlphaScreen (Perkin Elmer). B103 (Rat Neuroblast...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Neuropore Therapies

US Patent
LigandPNGBDBM580820(US11492348, Compound 32 | 5-(3-(benzylsulfonyl)-5-...)
Affinity DataIC50: 3.30E+4nMAssay Description:The substrate was prepared in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM D...More data for this Ligand-Target Pair
In DepthDetails
US Patent