BDBM577478 US11472830, Cpd No. 10

SMILES [BH3-][P@]1(=O)OCC2OC(C(O[P@@](S)(=O)OCC3OC(C(F)C3O1)n1cnc3c(N)ncnc13)C2OC)n1cnc2c1nc(N)[nH]c2=O

InChI Key InChIKey=PKQMBQOYPHOZIQ-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 577478   

TargetStimulator of interferon genes protein [139-379, H232R](Human)
Janssen Biotech

US Patent
LigandPNGBDBM577478(US11472830, Cpd No. 10)
Affinity DataIC50: 12nMAssay Description:The human STING SPA binding assay measures displacement of tritium labeled 2′, 3′cGAMP (cyclic (guanosine-(2′→5′)-monop...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein [H232R](Human)
Janssen Biotech

US Patent
LigandPNGBDBM577478(US11472830, Cpd No. 10)
Affinity DataKd:  1.58nMAssay Description:Compounds were analyzed on an 5200 biacore SPR instrument (GE Healthcare). E.coli produced truncated STING protein was immobilized on a series S stre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
Go to US Patent