BDBM577475 US11472830, Cpd No. 7

SMILES [BH3-][P@]1(=O)OCC2OC(C(O[P@@]([BH3-])(=O)OCC3OC(C(O)C3O1)n1cnc3c(N)ncnc13)C2O)n1cnc2c1nc(N)[nH]c2=O

InChI Key InChIKey=YMIIBMNOLHFVQM-UHFFFAOYSA-N

Data  1 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 577475   

TargetStimulator of interferon genes protein [139-379, H232R](Human)
Janssen Biotech

US Patent
LigandPNGBDBM577475(US11472830, Cpd No. 7)
Affinity DataIC50: 60nMAssay Description:The human STING SPA binding assay measures displacement of tritium labeled 2′, 3′cGAMP (cyclic (guanosine-(2′→5′)-monop...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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TargetStimulator of interferon genes protein [H232R](Human)
Janssen Biotech

US Patent
LigandPNGBDBM577475(US11472830, Cpd No. 7)
Affinity DataKd:  49nMAssay Description:Compounds were analyzed on an 5200 biacore SPR instrument (GE Healthcare). E.coli produced truncated STING protein was immobilized on a series S stre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein [H232R](Human)
Janssen Biotech

US Patent
LigandPNGBDBM577475(US11472830, Cpd No. 7)
Affinity DataKd:  1.27E+3nMAssay Description:Thermofluor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
Go to US Patent