BDBM577154 8-Cyclopropyl-10-(3,5-difluoro-4-methoxyphenyl)-7,8-dihydropyrrolo[1,2-a:4,5-b']dipyrazin-9(6H)-one::US11472805, Example 59

SMILES COc1c(F)cc(cc1F)-c1c2C(=O)N(CCn2c2nccnc12)C1CC1

InChI Key InChIKey=ABVXSVHDNRZRGD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 577154   

LigandPNGBDBM577154(US11472805, Example 59 | 8-Cyclopropyl-10-(3,5-dif...)
Affinity DataIC50: 12.6nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM577154(US11472805, Example 59 | 8-Cyclopropyl-10-(3,5-dif...)
Affinity DataIC50: 9.73nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM577154(US11472805, Example 59 | 8-Cyclopropyl-10-(3,5-dif...)
Affinity DataIC50: 87.7nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM577154(US11472805, Example 59 | 8-Cyclopropyl-10-(3,5-dif...)
Affinity DataIC50: 290nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
Go to US Patent