BDBM576074 8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo [3,4-b] pyrazin-6-yl)-2-fluoro-8-azaspiro [4.5] decan-1-amine::US11466017, Example 64A

SMILES N[C@@H]1[C@H](F)CCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl

InChI Key InChIKey=RIBDKTGIOVNZBA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 576074   

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
University Of Texas

US Patent
LigandPNGBDBM576074(US11466017, Example 64A | 8-(3-(2,3-Dichlorophenyl...)
Affinity DataIC50: 98nMAssay Description:Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
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