BDBM575622 (6-((2-amino-3-chloropyridin-4-yl)thio)-3- ((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5]decan-8-yl) pyrazin-2-yl)methanol::US11459340, Compound 1::US11702411, Compound 31

SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3ccnc(N)c3Cl)nc2CO)[C@@H]1N

InChI Key InChIKey=YQVDKPSNEOMNNC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 575622   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Nikang Therapeutics

US Patent
LigandPNGBDBM575622(US11459340, Compound 1 | (6-((2-amino-3-chloropyri...)
Affinity DataIC50: 0.900nMAssay Description:SHP2 possesses two N-terminal Src homology 2 (SH2) domains, a central protein-tyrosine phosphatase (PTP) domain, and C-terminal tail. At the basal st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2022
Entry Details
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TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Nikang Therapeutics

US Patent
LigandPNGBDBM575622(US11459340, Compound 1 | (6-((2-amino-3-chloropyri...)
Affinity DataIC50: 50nMAssay Description:The inhibition of SHP2 by compounds of the present disclosure (concentrations varying from 0.00005-10 μM) was monitored using an assay in which ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent