BDBM572253 3-ethyl-1-[3-(5-methylthiazol-2-yl)-1H-pyrrolo[2,3- b]pyridin-4-yl]piperidin-3-amine::US11447505, Example E177

SMILES CNC1CCCN(C1)c1ccnc2[nH]cc(-c3ncc(C)[nH]3)c12

InChI Key InChIKey=JQHSLDZAVPJKFZ-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 572253   

TargetSerine/threonine-protein kinase MRCK alpha(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM572253(3-ethyl-1-[3-(5-methylthiazol-2-yl)-1H-pyrrolo[2,3...)
Affinity DataKi:  0.0820nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2022
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase MRCK beta(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM572253(3-ethyl-1-[3-(5-methylthiazol-2-yl)-1H-pyrrolo[2,3...)
Affinity DataKi:  0.0890nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2022
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM572253(3-ethyl-1-[3-(5-methylthiazol-2-yl)-1H-pyrrolo[2,3...)
Affinity DataKi:  33.7nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2022
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM572253(3-ethyl-1-[3-(5-methylthiazol-2-yl)-1H-pyrrolo[2,3...)
Affinity DataKi:  96.2nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2022
Entry Details
Go to US Patent