BDBM567955 (R)-1-((R)-3-amino-1-(4-((6-amino-9H-purin-9-yl)methyl)-6-(2,4,5-trifluorophenyl)pyridin-3-yl)piperidin-3-yl)-2,2-difluoroethan-1-01 and (S)-1-((R)-3-amino-1-(4-((6-amino-9H-purin-9-yl) methyl)-6-(2,4,5-trifluorophenyl)pyridin-3-yl)piperidin-3-yl)-2,2-difluoroethan-1-ol::US11420970, Example 156
SMILES Nc1ncnc2n(Cc3cc(ncc3N3CCC[C@@](N)(C3)[C@@H](O)C(F)F)-c3cc(F)c(F)cc3F)cnc12
InChI Key InChIKey=RITHSQHPTNJAHO-UHFFFAOYSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 567955
Affinity DataIC50: 5.5nMAssay Description:This assay employed LC-MS/MS technology to monitor the SAH production from the NSD2 enzymatic reaction. The enzymatic reaction was performed in white...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of NSD3 degradation in human KMS-11 cells assessed as reduction in H3K36me2 levels by FRET assayMore data for this Ligand-Target Pair