BDBM567825 US11420970, Example 26

SMILES COC[C@@]1(N)CCCN(C1)c1cnc(cc1Cn1cnc2c(N)ncnc12)-c1cc(Cl)ccc1F

InChI Key InChIKey=FUEGZWGKKBGDBO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 567825   

TargetHistone-lysine N-methyltransferase NSD2(Human)
Novartis

US Patent
LigandPNGBDBM567825(US11420970, Example 26)
Affinity DataIC50: 5.5nMAssay Description:This assay employed LC-MS/MS technology to monitor the SAH production from the NSD2 enzymatic reaction. The enzymatic reaction was performed in white...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM567825(US11420970, Example 26)
Affinity DataIC50: 248nMAssay Description:Inhibition of human recombinant NSD1 incubated for 2 hrs by AlphaLISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM567825(US11420970, Example 26)
Affinity DataIC50: 1nMAssay Description:Inhibition of NSD3 degradation in human KMS-11 cells assessed as reduction in H3K36me2 levels by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed