BDBM565297 3-[([[2,6-dimethoxy-4-(2-methyl-1-oxo-2,7-naphthyridin-4-yl)phenyl]methyl](methyl)amino)methyl]-N-(5-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]pentyl)bicyclo[1.1.1]pentane-1-carboxamide ::US11414416, Compound D56::US11560381, Compound D56

SMILES COc1cc(cc(OC)c1CN(C)CC12CC(C1)(C2)C(=O)NCCCCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12)-c1cn(C)c(=O)c2cnccc12

InChI Key InChIKey=VUSRLKKHPAACTC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 565297   

TargetProtein SSX2/Protein SSXT(Human)
Foghorn Therapeutics

US Patent
LigandPNGBDBM565297(US11414416, Compound D56 | US11560381, Compound D5...)
Affinity DataIC50: 10nMAssay Description:This example demonstrates the ability of the compounds of the disclosure to degrade a Nano luciferase-BRO9 fusion protein in a cell-based degradation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
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TargetBromodomain-containing protein 9 [133-239](Human)
Foghorn Therapeutics

US Patent
LigandPNGBDBM565297(US11414416, Compound D56 | US11560381, Compound D5...)
Affinity DataIC50: 10nMAssay Description:Procedure: His-Flag-BRD9 (P133-K239; Swiss Prot Q9H8M2; SEQ ID NO:1 mgsshhhhhhenlyfq/gdykddddkgslevlfqg/PAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMII...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
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TargetBromodomain-containing protein 9 [133-239](Human)
Foghorn Therapeutics

US Patent
LigandPNGBDBM565297(US11414416, Compound D56 | US11560381, Compound D5...)
Affinity DataIC50: 10nMAssay Description:A mixture of biotinylated-ligand and SureLight Allophycocyanin-Streptavidin (APC-SA, PerkinElmer AD0201) in 50 mM HEPES (pH 7.4), 50 mM NaCl, 1 mM TC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
Go to US Patent