BDBM565183 N-(2-chloro-3-((5-ethynyl- 3-methyl-4-oxo-3,4- dihydroquinazolin-6- yl)amino)-4- fluorophenyl)propane-1- sulfonamide::US11414404, Ex. # 60::US11634409, Example 60

SMILES CCCS(=O)(=O)Nc1ccc(F)c(Nc2ccc3ncn(C)c(=O)c3c2C#C)c1Cl

InChI Key InChIKey=OSVHJQYCXNHYHC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 565183   

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Array Biopharma

US Patent
LigandPNGBDBM565183(US11414404, Ex. # 60 | N-(2-chloro-3-((5-ethynyl- ...)
Affinity DataIC50: 9.25nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Array Biopharma

US Patent
LigandPNGBDBM565183(US11414404, Ex. # 60 | N-(2-chloro-3-((5-ethynyl- ...)
Affinity DataIC50: 9.25nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
Go to US Patent