BDBM565176 N-(2-cyano-3-((3,5- dimethyl-4-oxo-3,4- dihdyroquinazolin-6- yl)amino)phenyl)propane- 1-sulfonamide::US11414404, Ex. # 53::US11634409, Example 53

SMILES CCCS(=O)(=O)Nc1cccc(Nc2ccc3ncn(C)c(=O)c3c2C)c1C#N

InChI Key InChIKey=YDOBOFOSXFWJFY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 565176   

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Array Biopharma

US Patent
LigandPNGBDBM565176(US11414404, Ex. # 53 | N-(2-cyano-3-((3,5- dimethy...)
Affinity DataIC50: 9.40nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Array Biopharma

US Patent
LigandPNGBDBM565176(US11414404, Ex. # 53 | N-(2-cyano-3-((3,5- dimethy...)
Affinity DataIC50: 9.40nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
Go to US Patent