BDBM565172 N-(2-chloro-3-((3,5- dimethyl-4-oxo-3,4- dihydroquinazolin-6- yl)amino)-4- fluorophenyl)benzene- sulfonamide::US11414404, Ex. # 49::US11634409, Example 49

SMILES Cc1c(Nc2c(F)ccc(NS(=O)(=O)c3ccccc3)c2Cl)ccc2ncn(C)c(=O)c12

InChI Key InChIKey=CTKGYEISZLITMU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 565172   

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Array Biopharma

US Patent
LigandPNGBDBM565172(US11414404, Ex. # 49 | N-(2-chloro-3-((3,5- dimeth...)
Affinity DataIC50: 3.95nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Array Biopharma

US Patent
LigandPNGBDBM565172(US11414404, Ex. # 49 | N-(2-chloro-3-((3,5- dimeth...)
Affinity DataIC50: 3.95nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
Go to US Patent